{"created":"2023-05-15T09:07:22.639716+00:00","id":14724,"links":{},"metadata":{"_buckets":{"deposit":"3d0fc80f-2ac5-44b2-ad46-311427cb7c49"},"_deposit":{"created_by":14,"id":"14724","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"14724"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014724","sets":["1658:1659:1722"]},"author_link":["25905","25906","25907","25902","25903","25904"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"307","bibliographicPageStart":"297","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Five anti-idiotypic monoclonal antibodies （anti-Id MoAbs） were generated from a BALB/c mouse immunized with anti-CEA MoAb MA208 in a syngeneic system. These anti-Id MoAbs specifically reacted to MoAb MA208 and inhibited CEA-MoAb MA208 binding. These results indicate that all of these anti-Id MoAbs recognized private idiotopes at the paratope of MoAb MA208. Mouse sera, which had been immunized by these anti-Id MoAbs, were analyzed to test the reactivity with CEA. Two kinds of mouse sera （immunized with anti-Id MoAbs M7-625 and M7-914） showed reactivity to CEA by binding assay, Western blot analysis and competition assay. These results sug- gest that anti-Id MoAbs M7-625 and M7-914 bear an \"internal image\" of the MA208-defined epitope onCEA. Anti-anti-Id MoAbs against anti-Id MoAb M7-914 revealed a cross-reactive idiotope for anti-Id MoAb M7-914 and M7-413. An amino acid analysis of the heavy chain of anti-Id MoAb M7-625 was performed. The result- ing amino acid sequence was compared with that of CEA. Some homologies between these two molecules were recognized at certain portions of CDR2 and CDR3 of MoAb M7-625 and domain III of CEA.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"25905","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tokuchi, Shigeru"}]},{"nameIdentifiers":[{"nameIdentifier":"25906","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsujisaki, Masayuki"}]},{"nameIdentifiers":[{"nameIdentifier":"25907","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Imai, Kohzoh"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.60.297","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"得地, 茂"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辻崎, 正幸"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今井, 浩三"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-31"}],"displaytype":"detail","filename":"n0036472X603297.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X603297.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14724/files/n0036472X603297.pdf"},"version_id":"4032f556-de29-4cbc-a708-b3c598e917fe"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CEA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Monoclonal antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-idiotypic antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cross-reactive idiotype","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Idiotype analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗CEAモノクローナル抗体に対する抗イディオタイプモノクローナル抗体の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗CEAモノクローナル抗体に対する抗イディオタイプモノクローナル抗体の解析","subitem_title_language":"ja"},{"subitem_title":"Analysis of Anti-idiotypic Monoclonal Antibodies to Anti-CEA Monoclonal Antibody","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["1722"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-31"},"publish_date":"2019-07-31","publish_status":"0","recid":"14724","relation_version_is_last":true,"title":["抗CEAモノクローナル抗体に対する抗イディオタイプモノクローナル抗体の解析"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T02:24:29.535306+00:00"}