@article{oai:sapmed.repo.nii.ac.jp:00014724,
 author = {得地, 茂 and 辻崎, 正幸 and 今井, 浩三},
 issue = {3},
 journal = {札幌医学雑誌 = The Sapporo medical journal, The Sapporo medical journal},
 month = {Jun},
 note = {Five anti-idiotypic monoclonal antibodies （anti-Id MoAbs） were generated from a BALB/c mouse immunized with anti-CEA MoAb MA208 in a syngeneic system. These anti-Id MoAbs specifically reacted to MoAb MA208 and inhibited CEA-MoAb MA208 binding. These results indicate that all of these anti-Id MoAbs recognized private idiotopes at the paratope of MoAb MA208. Mouse sera, which had been immunized by these anti-Id MoAbs, were analyzed to test the reactivity with CEA. Two kinds of mouse sera （immunized with anti-Id MoAbs M7-625 and M7-914） showed reactivity to CEA by binding assay, Western blot analysis and competition assay. These results sug- gest that anti-Id MoAbs M7-625 and M7-914 bear an "internal image" of the MA208-defined epitope onCEA. Anti-anti-Id MoAbs against anti-Id MoAb M7-914 revealed a cross-reactive idiotope for anti-Id MoAb M7-914 and M7-413. An amino acid analysis of the heavy chain of anti-Id MoAb M7-625 was performed. The result- ing amino acid sequence was compared with that of CEA. Some homologies between these two molecules were recognized at certain portions of CDR2 and CDR3 of MoAb M7-625 and domain III of CEA.},
 pages = {297--307},
 title = {抗CEAモノクローナル抗体に対する抗イディオタイプモノクローナル抗体の解析},
 volume = {60},
 year = {1991}
}