{"created":"2023-05-15T09:07:17.333013+00:00","id":14602,"links":{},"metadata":{"_buckets":{"deposit":"8bc028dc-6082-4d8f-98e4-dd9c0467df2c"},"_deposit":{"created_by":14,"id":"14602","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"14602"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014602","sets":["1658:1659:1730"]},"author_link":["25361","25362","25363","25364","25365","25356","25357","25358","25359","25360"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"58","bibliographicPageStart":"51","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A variety of paraneoplastic syndrome affects the central nervous system including eye. So far, two types of retinopathy are known to be associated with patients with malignancies, CAR （cancer-associated retinopathy）, and MAR （melanoma-associated retinopathy）. CAR is associated with epithelial cancers, mostly lung small cell carcinoma, and is characterized by retinitis pigmentosa-like retinal degeneration. Usually CAR can be found before an underlying primary cancer is diagnosed. While MAR is associated with cutaneous malignant melanoma and is characterized by the relatively sudden onset of photopsia and nyctalopsia. The flash ERG （electroretinogram） of MAR patient shows an negative waveform, reduced b-wave amplitude and reservation of a-wave amplitude, suggesting bipolar cells may be affected. CAR and MAR are believed to result from autoimune basis. In CAR, a calcium binding protein called recoverin, 70 kDa protein and neurofilament are found to be the retinal antigens recognized by patient's sera. In contrast, the retinal antigens in MAR have not yet been identified, although patient sera specifically recognized retinal bipolar cells in immunocytochemistry.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"25361","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ohguro, Hiroshi"}]},{"nameIdentifiers":[{"nameIdentifier":"25362","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Maeda, Akiko"}]},{"nameIdentifiers":[{"nameIdentifier":"25363","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ikeda, Yoko"}]},{"nameIdentifiers":[{"nameIdentifier":"25364","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Maeda, Tadao"}]},{"nameIdentifiers":[{"nameIdentifier":"25365","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ikuyo, Maruyama"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.68.51","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大黒, 浩"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"前田, 亜希子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"池田, 陽子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"前田, 忠郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"丸山, 幾代"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-31"}],"displaytype":"detail","filename":"n0036472X68451.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X68451.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14602/files/n0036472X68451.pdf"},"version_id":"f0bb938f-b355-406b-b8e2-7f9fbaefad5c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cancer-associated retinopathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Melanoma-associated retinopathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Autoimmunity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CAR antigen","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"癌関連網膜症の分子病態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌関連網膜症の分子病態","subitem_title_language":"ja"},{"subitem_title":"Molecular Pathology of Cancer-associated Retinopathy","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["1730"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-31"},"publish_date":"2019-07-31","publish_status":"0","recid":"14602","relation_version_is_last":true,"title":["癌関連網膜症の分子病態"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T02:21:39.122572+00:00"}