@article{oai:sapmed.repo.nii.ac.jp:00014519,
 author = {神保, 孝一 and 山下, 利春 and 松坂, 英信 and 廣崎, 邦紀 and 米田, 明弘 and 鎌田, 麻子 and 井上, 裕悦 and 肥田, 時征 and 川上, 聡経},
 issue = {3},
 journal = {札幌医学雑誌 = The Sapporo medical journal, The Sapporo medical journal},
 month = {Aug},
 note = {Management of malignant melanoma is a difficult challenge for physicians and basic scientists because cutaneous melanoma grows in the highly vascular tissue of epidermo-dermal interface and occurs at any age of generation. It can easily spread to distant organs and practically no treatment modality is available except for early diagnosis and surgical excision. In this report we review our current research efforts in establishing novel diagnostic and therapeutic approaches for malignant melanoma by exploiting our knowledge of basic biology in melanin and melanosome biogenesis. This is based upon the fact that melanin and melanosome biogenesis is biological property uniquely expressed in melanocytes, and highly accelerated and altered in their neoplastic counterpart, malignant melanoma. It is immediately apparent if one looks at the past literatures that rapid and significant progress of cancer management has been made if the biological property unique to cancer cells is exploited.},
 pages = {23--31},
 title = {Exploitation of Melanin and Melanosome Biogenesis for Better Management of Malignant Melanoma},
 volume = {74},
 year = {2005}
}