{"created":"2023-05-15T09:07:02.394729+00:00","id":14263,"links":{},"metadata":{"_buckets":{"deposit":"6a09a78d-424a-4d82-b391-558ae69408d1"},"_deposit":{"created_by":15,"id":"14263","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14263"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014263","sets":["1658:1661:1706"]},"author_link":["23933","23934","23935","23936","23937","23938","23939"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"66","bibliographicPageStart":"55","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Tumor Research"},{"bibliographic_title":"Tumor Research","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of the activated oncogene transfection on the expression of MHC class I H-2Kd, Dd and Ld and endogenous retroviral antigens was analyzed on 21 clones independently derived from the same parental BALB3T3. These clones were obtained by transfecting BALB3T3 with EJ-ras, PyMT, c-myc, and v-src oncogenes. The expression of MHC class I H-2Ld and H-2Kd antigens was reduced in clones with high anchorage independent growth potential. However, clones with low or no anchorage independent growth potential displayed almost the same degree of expression as parental BALB3T3. The H-2Dd antigen was for the most part conserved. The reduced expression of H-2Kd antigen was com-pletely restored by IFN treatment, whereas that of H-2Ld antigen was only par-tially restored. Meanwhile, MuLV and MMTV antigens were expressed on parental BALB3T3. These antigens was down-modulated in all of the EJ-ras and in one of the v-src-transfected clones. However, all the PyMT-transfected clones expressed the antigens as much as parental BALB3T3 even in the clones with high anchorage independent growth potential. These data suggest that the MHC class I antigen expression is modulated with the transforming process of cells, whereas the endogenous retroviral antigen expression might be dependent upon the transfected oncogenes rather than the transforming phenotype of the cells.","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/tr.26.55","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Sapporo Medical University"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0041-4093","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Torigoe, Toshihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Noriyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuura, Akihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nihei, Takehito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Qi, Weimin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Isao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kikuchi, Kokichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-31"}],"displaytype":"detail","filename":"n004140932655.pdf","filesize":[{"value":"571.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n004140932655.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14263/files/n004140932655.pdf"},"version_id":"3e2497c1-1a9e-43e8-9a27-692bf322cb32"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Class I antigen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Retroviral antigen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transformation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clonal Diversity of the Expression of MHC Class I Antigens. and Endogenous Retroviral Antigens on the Oncogene-Induced Cell Transformation of BALB3T3 Cells-Different Regulatory Mechanisms for the Expression of Antigens","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clonal Diversity of the Expression of MHC Class I Antigens. and Endogenous Retroviral Antigens on the Oncogene-Induced Cell Transformation of BALB3T3 Cells-Different Regulatory Mechanisms for the Expression of Antigens","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["1706"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-31"},"publish_date":"2019-07-31","publish_status":"0","recid":"14263","relation_version_is_last":true,"title":["Clonal Diversity of the Expression of MHC Class I Antigens. and Endogenous Retroviral Antigens on the Oncogene-Induced Cell Transformation of BALB3T3 Cells-Different Regulatory Mechanisms for the Expression of Antigens"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-13T02:46:05.352169+00:00"}