{"created":"2023-05-15T09:07:01.043362+00:00","id":14234,"links":{},"metadata":{"_buckets":{"deposit":"b1a7374e-bf34-46b8-af97-4e9bb4e84e5b"},"_deposit":{"created_by":15,"id":"14234","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14234"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014234","sets":["1658:1661:1710"]},"author_link":["23775","23776","23777","23778","23779","23780"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"46","bibliographicPageStart":"37","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"Tumor Research"},{"bibliographic_title":"Tumor Research","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cell adhesion kinase beta (CAKbeta) is the second protein-tyrosine kinase (PTK) of the focal adhesion kinase (FAK) subfamily with large N- and C-domains in addition to the central kinase domain but without Src homology 2 and 3 (SH-2 and SH-3) domains. In this paper, cloning and sequencing of a cDNA encoding human CAKβ are described. A full-length clone (clone B) contained 4,157- base pairs of human CAKβ cDNA including 243-base pairs of the 5'-untranslated sequence and 881-base pairs of the 3'-untranslated sequence with a polyadenyla-tion signal (ATTAAA). The clone B of human CAKβ cDNA has an open read-ing frame encoding 1009 amino acid residues ; the human CAKβ has the same number of amino acid residues in the N-, C-, and kinase-domains as rat CAKβ . The amino acid sequence of human CAKβ is 95.4% identical with that of rat CAKβ . The species difference is most prominent in the C-domain. All three previously-recognized, subfamily-specific residues in the kinase domains of FAK and the rat CAKβ are also found in the human CAKβ . The residues V??? and A???, which have been considered to be characteristic to CAKβ , are found to be conserved also in the human CAK? . It has been postulated that CAKβ is important as a docking protein. The autophosphorylation site and also the ligand site to the SH-2 domains of the Src-family PTKs, Y???AEI, are found to be conserved in the human CAKβ . The ligand sequence for the Grb2 SH-2 domain, Y???HNV of the rat CAKβ , is found functionally conserved in the human CAKβ , Y???LNV. The third ligand sequence, E???PPPKPSR, participating in the binding to the SH-3 domains of pp130cas and Efs, is also found conserved in the human CAKβ . The extreme N- terminal 88 amino acid residues of the rat CAKβ were previously found entirely different from FAK and found unique to CAK? . Ninety four percent of those 88 residues in the human CAKβ are found identical with the rat CAKβ . This high sequence homology strongly suggeststhat this region is involved in the specific function of CAKβ different from FAK.","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/tr.30.37","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Sapporo Medical University"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0041-4093","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sasaki, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagura, Kazuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishino, Masaho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohba, Takeaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuya, Manabu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Terukatsu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-31"}],"displaytype":"detail","filename":"n004140933037.pdf","filesize":[{"value":"515.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n004140933037.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14234/files/n004140933037.pdf"},"version_id":"c3bb988d-a761-45f1-a66a-6744b184f2cf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cell adhesion kinase β (CAKβ)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Focal adhesion kinase (FAK)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Autophosphorylation site","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Src homology 2 and 3 (SH-2 and SH-3) domains","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cloning of a cDNA for the Human Cell Adhesion Kinase  β","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cloning of a cDNA for the Human Cell Adhesion Kinase  β","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["1710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-31"},"publish_date":"2019-07-31","publish_status":"0","recid":"14234","relation_version_is_last":true,"title":["Cloning of a cDNA for the Human Cell Adhesion Kinase  β"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-13T02:45:08.696232+00:00"}