@article{oai:sapmed.repo.nii.ac.jp:00014169, author = {Zhang, Yubin and Adachi, Masaaki and Kawamura, Rina and Liu, Yaohua and Imai, Kohzoh and Hareyama, Masato and Shinomura, Yasuhisa}, journal = {Tumor Research, Tumor Research}, month = {}, note = {Radiation therapy is one of the main anticancer therapies. However, there are considerable numbers of radioresistant carcinoma cells and severe adverse effects occasionally occur after radiation therapy. Therefore, there have been many attempts to identify radiosensitizers. Histone hyperacetylation has begun to receive considerable attention as a potential target for radiosensitization. Inhibitors of histone deacetylase (HDAC) activity are becoming a major tool for modifying histone acetylation status. This article reviews the classification of HDAC inhibitors and their potential as radiosensitizers. We also discuss possible molecular mechanisms by which the HDAC inhibitors radiosensitize cancer cells.}, pages = {15--21}, title = {HDAC inhibitors as radiosensitizers}, volume = {41}, year = {2006} }