@article{oai:sapmed.repo.nii.ac.jp:00014133, author = {山下, 利春}, issue = {1-6}, journal = {札幌医学雑誌 = The Sapporo medical journal, The Sapporo medical journal}, month = {Dec}, note = {During my first 20 years at Sapporo Medical University, I was engaged primarily with tumor virology research in the Department of Molecular Biology, Cancer Research Institute. In the subsequent 18 years, my focus has been on research of melanocytes and melanoma in the Department of Dermatology. I have been involved in many research fields including transforming genes of human adenoviruses and human papillomaviruses (HPVs), tumor suppressor genes, adenovirus vectors, melanin biosynthesis, molecular biology of melanoma, topical treatment of skin cancer, skin-whitening agent and reactive oxygen species (ROS) and diagnosis of xeroderma pigmentosum. In this present report, I describe several research projects with which I struggled until publications. These include expression of adenovirus transforming genes, structure and function of HPV16 E6E7 genes, construction of recombinant adenoviruses, depigmentation induced by cosmetics and diagnosis of complementation groups of xeroderma pigmentosum through the use of adenovirus vectors. It is my sincere hope that this manuscript will be able to provide some semblance of assistance and encouragement to young doctors and medical students}, pages = {1--5}, title = {札幌医科大学における38年間の研究について}, volume = {84}, year = {2015} }