{"created":"2023-05-15T09:06:22.768583+00:00","id":13043,"links":{},"metadata":{"_buckets":{"deposit":"e3610423-39ca-4605-bd91-655ba7dad950"},"_deposit":{"created_by":14,"id":"13043","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"13043"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00013043","sets":["1875:1885:1992"]},"author_link":["19646","19647","19648","19649","19650","19651","19652","19653","19654","19655"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-10-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"13","bibliographicPageStart":"9","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"市立室蘭総合病院医誌 = Journal of Muroran City General Hospital"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"症例は67歳、女性。28歳発症の関節リウマチ（rheumatoid arthritis；RA）に対し、約10年前よりメトトレキサート（methotrexate；MTX）を内服していた。平成24年4月中旬より、左前胸部に増大傾向を示す皮下腫瘤が出現。他院で皮膚生検を行い、diffuse large B cell lymphoma（DLBCL）と診断され、同年5月に当科を紹介受診。各種検査を行ったが、皮膚以外に病変は指摘できなかった。MTX 内服中のRA 患者に発生したDLBCL であり、メトトレキサート関連リンパ増殖性疾患（MTX-associated lymphoproliferative disorder；MTX-LPD）の可能性も考慮し、すぐには抗癌剤治療を行わず、まずはMTX を休薬した結果、皮膚病変は1週間で色素沈着を残した状態で退縮したため、本症例はMTX-LPD と診断された。現在に至るまで、悪性リンパ腫の再発兆候はなく経過している。MTX-LPD は、今回の症例のようにMTX の休薬のみで腫瘍が自然退縮する例もあるため、MTX 内服中のRA 患者に発症する節外性悪性リンパ腫の鑑別疾患の1つとして、常にMTX-LPD を念頭に置く必要があると考えられた。","subitem_description_type":"Abstract"}]},"item_2_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"市立室蘭総合病院"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0289-2774","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐々木, 基"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐藤, 修司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"飯田, 智哉"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"永縄, 由美子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石上, 敬介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中垣, 卓"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"清水, 晴夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"金戸, 宏行"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小西, 康宏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今, 信一郎"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-21"}],"displaytype":"detail","filename":"n028927743919.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n028927743919.pdf","url":"https://sapmed.repo.nii.ac.jp/record/13043/files/n028927743919.pdf"},"version_id":"fcea69fb-23cf-4e20-8bd5-31c3da6cd81e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"メトトレキサート","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫不全関連リンパ増殖性疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"悪性リンパ腫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"関節リウマチ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"皮膚原発メトトレキサート関連リンパ増殖性疾患の1例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"皮膚原発メトトレキサート関連リンパ増殖性疾患の1例","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"14","path":["1992"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-10-24"},"publish_date":"2014-10-24","publish_status":"0","recid":"13043","relation_version_is_last":true,"title":["皮膚原発メトトレキサート関連リンパ増殖性疾患の1例"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T03:10:19.877634+00:00"}