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ガンマナイフ照射がラット総頸動脈の弛緩および収縮反応に及ぼす影響
https://sapmed.repo.nii.ac.jp/records/8081
https://sapmed.repo.nii.ac.jp/records/808127740e38-f700-4a48-80ad-c105ee3317ec
名前 / ファイル | ライセンス | アクション |
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n134057648159.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-03-24 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | ガンマナイフ照射がラット総頸動脈の弛緩および収縮反応に及ぼす影響 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | gamma knife radiosurgery | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | common carotid artery | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | endothelium | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | smooth muscle | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | rat | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
高橋, 州平
× 高橋, 州平× 戸島, 雅彦× 福岡, 誠二× 瀬尾, 善宣× 末松, 克美× 中村, 順一× 長嶋, 和郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This report concerns a pilot study of the short- and long-term effects of gamma knife radiosurgery on vascular responses. The investigation was carried out on male Sprague-Dawley rats, and the relaxation and contraction responses of the right common carotid artery (CCA) were assessed following irradiation (100 Gy). The non-treated CCA of the same animals served as internal controls. Non-irradiated rats were used to control the effect of normal aging on vascular function. Isometric tension was determined on in vitro preparations of arterial rings. Acetylcholine-mediated, endothelium-dependent relaxation was impaired one month after radiosurgery, as was endothelium-independent relaxation induced by sodium nitroprusside, but the effect on the later was minimal. The irradiated CCA was also impaired with respect to contraction responses induced by- norepinephrine, endothelin-1 or phorbol dibutyrate. This impairment appeared to be biphasic, as it was evident one day after radiosurgery, followed by a partial recovery one week later, and again manifest after one month. At the light microscope level, the carotid arteries appeared to be well preserved throughout the experiment. However, obvious ultrastructural changes were noted in endothelial and smooth muscle cells of specimens obtained three months after radiosurgery. The present data indicate that high dose gamma knife radiosurgery affects the functions of both, the vascular endothelium and the vascular smooth muscles in an apparent time-dependent fashion. Because of its increasing application to patients, there is the need for studying the effects of gamma knife radiosurgery on cerebral arteries, since functional vascular changes may occur in the absence of obvious histological alterations. Our results on CCAs point to the feasibility of such experimental investigations. | |||||
書誌情報 |
北海道脳神経疾患研究所医誌 = Journal of Hokkaido Brain Research Foundation 巻 8・9, 号 1, p. 59-71, 発行日 1997-12-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1340-5764 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | Effect of gamma knife radiosurgery on relaxation and contraction responses of the common carotid artery of the rat | |||||
出版者 | ||||||
出版者 | 中村記念病院 |