WEKO3
アイテム
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実験的ウサギクモ膜下出血後の脳底動脈攣縮モデル
https://sapmed.repo.nii.ac.jp/records/8080
https://sapmed.repo.nii.ac.jp/records/8080f8f8f8f0-5fec-455f-8e4f-f242c87d5c67
名前 / ファイル | ライセンス | アクション |
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n134057648139.pdf (15.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-03-24 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 実験的ウサギクモ膜下出血後の脳底動脈攣縮モデル | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Subarachnoid hemorrhage | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Basilar artery | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cerebral vasospasm | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cerebral angiography | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Rabbit | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
北條, 敦史
× 北條, 敦史× 高橋, 州平× 末松, 克美× 中村, 順一 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To evaluate the preventive efficacy of various antispastic agents on cerebral vasospasm after subarachnoid hemorrhage (SAH) in vivo, we consider it is very important to establish to make a reliable animal SAH model. This report concerns how to make a model of a rabbit basilar artery vasospasm after SAH at Hokkaido Brain Reseach Foundation. On day-0, a male Japanese-white rabbit weighing between 3.0kg and 3.7kg, was anesthetized with an intravenous injection of pentobarbital (25mg/kg) and pancronium bromide (0.3mg/kg). On day-2, smaller anesthetics (pentobarbital 20mg/kg, pancronium bromide 0.2mg/kg) were administered because the animal lost body weight as well as activity. Tracheal intubation and artificial ventilation were performed. The central ear artery was cannulated to measure arterial blood pressure. Arterial blood gas (paO2, paCO2) was maintained within physiological range. On day-0 and day-2, the basilar artery angiography was performed. On day-0, after the angiography, cisterna magna was punctured with 23-guage butterfly needle and injected 5.0ml autologous arterial blood. Diameter of basilar artery on the angiogram was measured and the vasospasm ratio was estimated between pre and post SAH. On day-2, after the angiography, the rabbit was perfused and fixed, then the brain was removed to evaluate amount of subarachnoid colt and the basilar artery was pathologically examined. In our institute, now we have already established this animal model so can always investigate the effectiveness of various antispastic agents for SAH in vivo. | |||||
書誌情報 |
北海道脳神経疾患研究所医誌 = Journal of Hokkaido Brain Research Foundation 巻 8・9, 号 1, p. 39-58, 発行日 1997-12-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1340-5764 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | Cerebral Vasospasm Model of Experimental Subarachnoid Hemorrhage in Rabbit | |||||
出版者 | ||||||
出版者 | 中村記念病院 |