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Matrix Metalloproteinase Matrilysin in Cancers of the Digestive Organs
https://sapmed.repo.nii.ac.jp/records/7536
https://sapmed.repo.nii.ac.jp/records/7536ec881b90-ae59-4082-83ed-db3d4cb8ab0a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
n004140933511.pdf (734.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2009-03-09 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Matrix Metalloproteinase Matrilysin in Cancers of the Digestive Organs | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | Matrix metalloproteinases | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | Matrilysin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | Tumor invasiveness | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | Tumor metastasis | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Yamamoto, Hiroyuki
× Yamamoto, Hiroyuki
× Itoh, Fumio
× Adachi, Yasushi
× Iku, Shouhei
× Fukushima, Hiroshi
× Horiuchi, Shina
× Sasaki, Shigeru
× Arimura, Yoshiaki
× Endo, Takao
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| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | Matrix metalloproteinase (MMP) matrilysin has been implicated in tumor invasion and metastasis as well as in tumor initiation and growth in gastrointestinal and other cancers. As a MMP,matrilysin is unique in its minimum MMP structure,wide spectrum of substrate specificity,potency for starting an activation cascade of MMPs,and,most notably,in its production by cancer cells themselves.The production by cancer cells themselves could be an advantage as a biological marker of themalignant phenotype.indeed,we have found that matrilysin expression at the invasive front is correlated with the progression of gastric,colorectal,hepatocellular,and pancreatic carcinomas as well as esophageal squamous cell carcinoma.We have also revealed the correlation of matrilysin expression with recurrence and/or poor prognosis in carcinomas of the colorectum,liver,pancreas, and esophagus.Another advantage is its susceptibility to direct therapeutic intervention.Inhibition of matrilysin by an antisense expression vector or antisense oligonucleotides has been demonstrated to suppress the in vitro invasive potential or in vivo metastatic potential of gastric,colonic,and pancreatic cancer cells. The crucial roles of MMPs,especially those of matrilysin,in cancers have thus generated considerable interest in the use of synthetic MMP inhibitors as potential therapeutic agents. Matrilysin could be a promising therapeutic molecular target for cancers of the digestive org | |||||||||||||||||||||||
| 書誌情報 |
Tumor Research 巻 35, p. 1-12, 発行日 2000 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 0041-4093 | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | 10.15114/tr.35.1 | |||||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Sapporo Medical University | |||||||||||||||||||||||
