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尿中 Light Chain に関する臨床的研究
https://doi.org/10.15114/smj.48.520
https://doi.org/10.15114/smj.48.52059b035ce-7293-4e8d-908f-5a6828604787
名前 / ファイル | ライセンス | アクション |
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n0036472X485520.pdf (5.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-08-23 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 尿中 Light Chain に関する臨床的研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Clinical Investigation of Free Light Chains in Urine | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.48.520 | |||||
ID登録タイプ | JaLC | |||||
著者 |
須藤, 稔
× 須藤, 稔× 谷内, 昭 |
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著者別名 | ||||||
姓名 | Minoru, Sudoh | |||||
著者別名 | ||||||
姓名 | Akira, Yachi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Antisera against free light (FL) chains were prepared and the determination of urinary FL chain was carried out by the single radial immunodiffusion technique clinically in various diseases including monoclonal gammopathy (M'-proteinemia) and malignant neoplasms. The results obtained are as follows. 1) Determinations of both free κ- and λ-chains (Fκ and Fλ) showed good reproducibility in concentrations between 10 to 80mg/dl by use of the standard samples of κ- and/or λ-chain dimer. The error caused by the monomer was negligible in most of the urinary specimens except for those of monomeric Bence-Jones proteinuria. 2) The mean urinary excretions of Fκ and Fλ in control subjects were 4.3 and 0.9mg/day, respectively. The ratio of κ- to λ-chain was in general around 4.8:1 showing a tendency of κ-dominance. 3) A significant increase in urinary excretion of Fκ was found in the aged control as compared with the adult control whereas the relation of Fλ to aging was not clearly seen. 4) In diseases with M-proteinemia, FL chains coincident with the light chain types of serum M-proteins were elevated in urine and identified as Bence-Jones proteins. The serial determinations of these appeared to be useful as a monitor of patients with M-proteinemia. 5) It was noted that urinary excretion of FL chains different from light chain types of serum M-proteins increased together with Bence-Jones proteins. These FL chains were confirmed to be polyclonal in nature by immunoelectrophoresis. 6) Polyclonal FL chains often increased in urine from patients with cancer, leukemia and systemic lupus erythematodes, and only one of either Fκor Fλ increased in urine from some patients. Therefore,it was conjectured that an imbalance in immunoglobulin synthesis might be involved in these disease conditions, and a possible relevance to hypergammaglobulinemia was considered to be one of the factorscausing the increase of FL chain excretion in urine. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 48, 号 5, p. 520-532, 発行日 1979-10-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |