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向精神薬による錐体外路症状出現に関する神経薬理学的考察 : 遅発性ジスキネジアを中心に
https://doi.org/10.15114/smj.55.487
https://doi.org/10.15114/smj.55.48771f15165-7039-4374-b8d0-352e40aa0a19
名前 / ファイル | ライセンス | アクション |
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n0036472X555487.pdf (554.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-08-23 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 向精神薬による錐体外路症状出現に関する神経薬理学的考察 : 遅発性ジスキネジアを中心に | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Neuropharmacological Consideration on the Pathogenesis of Tardive Dyskinesia | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neostriatum | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neurotransmitter | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Chemical anatomy | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Receptor supersensitivity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.55.487 | |||||
ID登録タイプ | JaLC | |||||
著者 |
石沢, 秀明
× 石沢, 秀明× 斎藤, 利和 |
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著者別名 | ||||||
姓名 | Ishizawa, Hideaki | |||||
著者別名 | ||||||
姓名 | Saito, Toshikazu | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Antipsychotic agents have been widely used since their introduction in psychiatric practice. Their side effects have been well recognized. One side effect is the occurrence of tardive dykinesia. We reviewed the chemical anatomy of the neostriatum (caudate and putamen), and distinguished two major efferent systems (SI system and SII system). Firstly, we proposed the hypothesis that tardive dyskinesia is related to SII system hypofunction. The transmitter-receptor systems of the neostriatum were also disccussed, and the balance mechanism between them was stressed in the pathogenesis of tardive dyskinesia. We reviewed the relationship between tardive dyskinesia and drug induced Pakinsonism. CSF examination of tardive dyskinesia and drug induced Parkinsonism showed similar changes (i. e., increased HVA concentration). These two diseases might have a common prerequisite, and additional conditions might determine which disease develops. The receptoe blockade mechanism and supersensitivity seemed to play a key role in the appearance of the disease. To elucidate the pathogenesis of tardive dyskinesia and drug induced Parkinsonism further examination is critically needed. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 55, 号 5, p. 487-493, 発行日 1986-10-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |