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ヒト子宮頸部腺癌培養細胞株(CAC-1)の樹立とその性状および各種抗癌剤に対する感受性の検討
https://doi.org/10.15114/smj.57.603
https://doi.org/10.15114/smj.57.6036e1b8b91-ec6d-4561-b434-0b7bba570532
名前 / ファイル | ライセンス | アクション |
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n0036472X576603.pdf (4.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-08-16 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | ヒト子宮頸部腺癌培養細胞株(CAC-1)の樹立とその性状および各種抗癌剤に対する感受性の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Establishment and Characterization of a Cell Line Derived from Human Uterine Cervical Adenocarcinoma and Its Chemosensitivity to Anticancer Drugs | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Established cell line | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Uterine cervical adenocarcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CA-125 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Chemosensitivity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | In vitro colony forming assay | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.57.603 | |||||
ID登録タイプ | JaLC | |||||
著者 |
早川, 修
× 早川, 修× 山内, 修× 工藤, 隆一× 山本, 裕之× 小泉, 基生× 竹原, 正輝 |
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著者別名 | ||||||
姓名 | Hayakawa, Osamu | |||||
著者別名 | ||||||
姓名 | Kudo, Ryuichi | |||||
著者別名 | ||||||
姓名 | Yamamoto, Hiroyuki | |||||
著者別名 | ||||||
姓名 | Kotsumi, Motoiki | |||||
著者別名 | ||||||
姓名 | Yamaucie, Osamu | |||||
著者別名 | ||||||
姓名 | Takehara, Masaki | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A new cell line of a human uterine cervical adenocarcinoma, designated as CAC-1, was established from a moderately differentiated adenocarcinoma of the uterine cervix. CAC-1 was subcultivated more than 150 times during 36 month period. The population doubling time was 31 hours. The number of chromosomes in the majority of cells was hypertriploidy with a mode of 75 at passage 51. In the cytoplasm, alcian blue, PAS and CEA staining positive substances could be seen. The cells produced CA-125, hCG and TPA in cultured media. The tumor obtained from nude mice inoculated with CAC-1 cells was a moderately differentiated adenocarcinoma histologically, closely resembling the original human tumor. CAC-1 was studied for chemosensitivity against 12 anticancer drugs by in vitro colony forming assay. In vitro sensitivity was defined as a 70% or greater inhibition of colony formation when compared to controls. Etoposide, mitomycin C and cisplatin showed sensitivity at peak plasma concentrations for 1 hour exposure. The 8 drugs, which showed sensitivity at 1/10 peak plasma concentration for 24 hour exposure, were aclacinomycin, actinomycin D, mitomycin C, etoposide, adriamycin, vincristine, vinblastine and cisplatin. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 57, 号 6, p. 603-611, 発行日 1988-12-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |