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肝, 胆道系における局所免疫機構の解析 : HRPによる総胆管感作ラットでの検討
https://doi.org/10.15114/smj.57.485
https://doi.org/10.15114/smj.57.48551cb8c05-c0a7-4220-83bd-1a7f334370db
名前 / ファイル | ライセンス | アクション |
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n0036472X575485.pdf (2.8 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-08-16 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 肝, 胆道系における局所免疫機構の解析 : HRPによる総胆管感作ラットでの検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Studies on the Local Immune Mechanism in the Hepatobiliary Tract of the Rat : Immunological Analysis of the Liver and Bile after Retrograde Injection of HRP into the Common Bile Duct | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Bile | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Secretory lgA | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Lymphoid tissue | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Hepatobiliary system | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Local immunity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.57.485 | |||||
ID登録タイプ | JaLC | |||||
著者 |
坂内, 文男
× 坂内, 文男× 吉田, 豊× 服部, 淳夫 |
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著者別名 | ||||||
姓名 | Sakauchi, Fumio | |||||
著者別名 | ||||||
姓名 | Yoshida, Yutaka | |||||
著者別名 | ||||||
姓名 | Hattori, Atsuo | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A new experimental model was developed in rats to investigate the local immune mechanism in the hepatobiliary tract. Animals were initially sensitized with subcutaneous injection of horseradish peroxidase(HRP) in the hind foot pads followed by retrograde boosting with the same antigen through the common bile duct 8 weeks after the initial sensitization(ID-rat). Rats which were boosted intravenously with HRP (IV-rat), which recieved HRP into the common bile duct without initial sensitization(S-rat), and normal rats served as control. The number of anti-HRP antibody forming cells increasd significantly in the portal triad of the liver in the ID-rats. These cells were shown to be positive for lgA by double immunohistochemistry for HRP and lgA. The amount of lgA in the bile also increased in the ID-rats. Immunoblotting after PAGE of the bile revealed the presence of anti-HRP antibody activity. The specific anti-HRP antibody activity in the bile corresponded with secretory lgA. These results indicated that the hepatobiliary system responds to antigenic stimulus by producing specific lgA antibody, and the lymphoid cells localized in the portal triad might serve as the hepatobiliary tract-associated lymphoid tissue, the same as GALT and BALT. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 57, 号 5, p. 485-494, 発行日 1988-10-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |