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胃および十二指腸潰瘍におけるimmunoreactivegroupIpepsinogen (PGI) の血中動態ならびに胃粘膜組織内分布
https://doi.org/10.15114/smj.57.407
https://doi.org/10.15114/smj.57.40773440520-d235-4094-8f11-a6a074efbd04
名前 / ファイル | ライセンス | アクション |
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n0036472X574407.pdf (2.7 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-08-16 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 胃および十二指腸潰瘍におけるimmunoreactivegroupIpepsinogen (PGI) の血中動態ならびに胃粘膜組織内分布 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Changes in Serum Group I Pepsinogen(PG I) Levels and Distribution of Immunoreactive PG I in Gastric Mucosa in Patients with Gastric or Duodenal Ulcer | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Group I pepsinogen (PGI) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | PGI cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Peptic ulcer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Gastric pepsin secretions | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Gastric mucosal protection | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.57.407 | |||||
ID登録タイプ | JaLC | |||||
著者 |
藤井, 謙
× 藤井, 謙× 矢花, 剛 |
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著者別名 | ||||||
姓名 | Fujii, Ken | |||||
著者別名 | ||||||
姓名 | Yabana, Tsuyoshi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In order to clarify the mechanism of hyper-group I pepsinogenemia in patients with gastric or duodenal ulcer (GU or DU), fasting serum group I pepsinogen (PGI) and changes of PGI levels in serum and of pepsin secretions in gastric juice following various stimulations were studied. Simultaneously, immunoreactive PGI (IR-PGI) concentrations and the number of PGI positive cell in the gastric mucosa were also examined. The results were as follows: 1) Fasting serum PGI levels were higher in the active, healing and scarring stages of GU and DU patients, respectively than those in normal controls (p<0.01). The levels, however, decreased gradually following the healing of ulcers. 2) In GU and DU patients, serum PGI levels significantly increased following insulin-induced hypoglycemia. The response patterns of serum PGI after insulin-stimulation were roughly classified into three types: fluctuating type (type A), delayed elevation type (type B) and low response type (type C). Gastric mucosal manifestations and excessive acid and pepsin secretions in GU and DU patients were often found in type A. In GU patients, serum PGI levels increased after secretin stimulation. However, they did not increase in DU patients. 3) Pepsin output (POP) in gastric juice of normal controls and patients with GU or DU showed significant increase by insulin-induced hypoglycemia. Secretin stimulation markedly increased POP in DU patients as compared with normal controls or GU patients. 4) IR-PGI concentrations and number of IR-PGI positive cell in fundic mucosa obtained by endoscopy or surgery showed a good correlation (r=0.91, p<0.01) and were significantly higher in DU than in GU patients. ?These results suggest that the mechanism involved in hyper-group I pepsinogenemia is different between both ulcers. Namely, the hyper-group I pepsinogenemia in GU patients may be caused relevant to a leakage of PGI from chief cells under breakdown state in the gastric mucosal protection mechanism, whereas in DU patients it may be associated with the marked increase of chief cells. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 57, 号 4, p. 407-422, 発行日 1988-08-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |