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Estrogen Receptor, 内因性EstradiolおよびEpidermal Growth Factor Receptor と乳癌の増殖活性の関連
https://doi.org/10.15114/smj.59.1
https://doi.org/10.15114/smj.59.1f9adf9e9-0a45-4191-a748-55dbd65f5bdc
名前 / ファイル | ライセンス | アクション |
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n0036472X5911.pdf (1.5 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-08-16 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | Estrogen Receptor, 内因性EstradiolおよびEpidermal Growth Factor Receptor と乳癌の増殖活性の関連 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Relationship of Estrogen Receptor, Endogenous Estradiol and Epidermal Growth Factor Receptor to the Proliferative Activity of Breast Cancer | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Human breast cancer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Estrogen receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Epidermal growth factor receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Endogenous estradiol | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | DNA polymerase α | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.59.1 | |||||
ID登録タイプ | JaLC | |||||
著者 |
三神, 俊彦
× 三神, 俊彦× 成松, 英明 |
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著者別名 | ||||||
姓名 | Mikami, Toshihiko | |||||
著者別名 | ||||||
姓名 | Narimastu, Eimei | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In order to evaluate the relationship of the expression of estrogen receptor (ER), endogenous estradiol (E2) and epidermal growth factor receptor (EGFR) to the proliferative activity of primary breast cancers, immunohistochemical studies were performed on 71 cases of primary breast cancer. Proliferative activity was evaluated by using anti-DNA polymerase α monoclonal antibody, CL22-2-42B, which reacts with cells in the proliferation cycle. The percentage of positive stained cancer cells was calculated and used as an indicator of the proliferative activity of each specimen. The relation of ER, endogenous E2 and EGFR to the proliferative activity was investigated. The results are summarized as follows: 1. The ER positive breast cancers had a lower proliferative activity than the ER negative breast cancers. 2. Among the ER positive breast cancers, E2 positive cancers had higher proliferative activity than E2 negative cancers. Thus endogenous E2 seems to play a role in the proliferation of ER positive breast cancers. 3. EGFR positive cancers had higher proliferative activity than EGFR negative cancers. 4. ER(-) EGFR(+) tumors had greater proliferative activity than ER (+) EGFR (-) tumors. The expression of EGFR relates much more closely to higher proliferative activity of breast cancer than ER. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 59, 号 1, p. 1-11, 発行日 1990-02-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |