WEKO3
アイテム
{"_buckets": {"deposit": "2a472263-d27c-4713-9b2e-d7c905216853"}, "_deposit": {"created_by": 14, "id": "14802", "owners": [14], "pid": {"revision_id": 0, "type": "depid", "value": "14802"}, "status": "published"}, "_oai": {"id": "oai:sapmed.repo.nii.ac.jp:00014802", "sets": ["1720"]}, "author_link": ["26256", "26257", "26254", "26255"], "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1989-02-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "24", "bibliographicPageStart": "15", "bibliographicVolumeNumber": "58", "bibliographic_titles": [{"bibliographic_title": "札幌医学雑誌 = The Sapporo medical journal"}, {"bibliographic_title": "The Sapporo medical journal", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The effects of desipramine (DMI) treatment on a rat cortical beta-adrenergic receptor- coupled adenylate cyclase (AC) system were investigated. Continuous treatment (1-3 days) of rats with desipramine (10 mg/kg, twice per day) caused a decrease in guanyl-5\u0027 -yl-imidodiphosphate [Gpp(NH)p]- stimulated AC activity in the cerebral cortical membrane. The decrease in the [Gpp(NH)p] - stimulated AC activity was more rapid and greater than the decrease in the number of beta-receptors in the cerebral cortical membrane of desipramine treated rats, indicating that the decrease in the enzyme activity, occurring at an early stage of the treatment, was not accounted for solely by the decrease in the receptor number. Although AC activity in the presence of a saturated level of Gpp(NH)p (Vmax) was not altered, the concentration of Gpp(NH)p required for the half-maximal activation of AC (EC?? for activation) was shifted from 0.73μM to 1.62μM in the membrane of 3 day-DMI treated rats. However, the concentration of Gpp(NH)p required for the half maximal inhibition of forskolin-stimulated AC (EC?? for inhibition) was not altered by 3 day-DMI treatment. The time course of activation of cortical AC activity by Gpp(NH)p was altered and the T1/2 for activation increased from 1.3 minutes to 2.0 minutes by the 3 day-DMI treatment. Three day-DMI treatment caused a decrease in the EC?? value for isoproterenol activation of AC from 30.7 nM to 22.9 nM in the rat cortical membrane. These results suggest that DMI decreases the affinity of Gs-protein to guanine nucleotides and consequently inhibits the high-affinity state breakdown process of beta-adrenergic receptor in the receptor-AC coupling system of the rat cerebral cortex. However, DMI has no or little effect on Gi protein.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "26256", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Tsuchiya, Fumiaki"}]}, {"nameIdentifiers": [{"nameIdentifier": "26257", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Saito, Toshikazu"}]}]}, "item_7_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.15114/smj.58.15", "subitem_identifier_reg_type": "JaLC"}]}, "item_7_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "札幌医科大学医学部"}]}, "item_7_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0036-472X", "subitem_source_identifier_type": "ISSN"}]}, "item_7_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "土屋, 文明"}], "nameIdentifiers": [{"nameIdentifier": "26254", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "齋藤, 利和"}], "nameIdentifiers": [{"nameIdentifier": "26255", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "n0036472X58115.pdf", "filesize": [{"value": "744.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 744100.0, "url": {"label": "n0036472X58115.pdf", "url": "https://sapmed.repo.nii.ac.jp/record/14802/files/n0036472X58115.pdf"}, "version_id": "743e24e4-2c94-4998-8f34-e521e0fda2e0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Desipramine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "β-adrenoceptor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Adenylate-cyclase", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "G-proteins", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "三環系抗うつ薬desipramineのラット大脳皮質β-adrenaline受容体adenylatecyclase共役機構への影響", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "三環系抗うつ薬desipramineのラット大脳皮質β-adrenaline受容体adenylatecyclase共役機構への影響", "subitem_title_language": "ja"}, {"subitem_title": "Effect of Chronic Desipramine Administration on fi-adrenoceptor Adenylate Cyclase Coupling in Rat Cerebral Cortex", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "14", "path": ["1720"], "permalink_uri": "https://doi.org/10.15114/smj.58.15", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-08-16"}, "publish_date": "2019-08-16", "publish_status": "0", "recid": "14802", "relation": {}, "relation_version_is_last": true, "title": ["三環系抗うつ薬desipramineのラット大脳皮質β-adrenaline受容体adenylatecyclase共役機構への影響"], "weko_shared_id": -1}
三環系抗うつ薬desipramineのラット大脳皮質β-adrenaline受容体adenylatecyclase共役機構への影響
https://doi.org/10.15114/smj.58.15
https://doi.org/10.15114/smj.58.15adeb4f8c-ae52-494f-bf24-c8bef663ba3d
名前 / ファイル | ライセンス | アクション |
---|---|---|
n0036472X58115.pdf (744.1 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-08-16 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 三環系抗うつ薬desipramineのラット大脳皮質β-adrenaline受容体adenylatecyclase共役機構への影響 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of Chronic Desipramine Administration on fi-adrenoceptor Adenylate Cyclase Coupling in Rat Cerebral Cortex | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Desipramine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | β-adrenoceptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Adenylate-cyclase | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | G-proteins | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.58.15 | |||||
ID登録タイプ | JaLC | |||||
著者 |
土屋, 文明
× 土屋, 文明× 齋藤, 利和 |
|||||
著者別名 | ||||||
姓名 | Tsuchiya, Fumiaki | |||||
著者別名 | ||||||
姓名 | Saito, Toshikazu | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effects of desipramine (DMI) treatment on a rat cortical beta-adrenergic receptor- coupled adenylate cyclase (AC) system were investigated. Continuous treatment (1-3 days) of rats with desipramine (10 mg/kg, twice per day) caused a decrease in guanyl-5' -yl-imidodiphosphate [Gpp(NH)p]- stimulated AC activity in the cerebral cortical membrane. The decrease in the [Gpp(NH)p] - stimulated AC activity was more rapid and greater than the decrease in the number of beta-receptors in the cerebral cortical membrane of desipramine treated rats, indicating that the decrease in the enzyme activity, occurring at an early stage of the treatment, was not accounted for solely by the decrease in the receptor number. Although AC activity in the presence of a saturated level of Gpp(NH)p (Vmax) was not altered, the concentration of Gpp(NH)p required for the half-maximal activation of AC (EC?? for activation) was shifted from 0.73μM to 1.62μM in the membrane of 3 day-DMI treated rats. However, the concentration of Gpp(NH)p required for the half maximal inhibition of forskolin-stimulated AC (EC?? for inhibition) was not altered by 3 day-DMI treatment. The time course of activation of cortical AC activity by Gpp(NH)p was altered and the T1/2 for activation increased from 1.3 minutes to 2.0 minutes by the 3 day-DMI treatment. Three day-DMI treatment caused a decrease in the EC?? value for isoproterenol activation of AC from 30.7 nM to 22.9 nM in the rat cortical membrane. These results suggest that DMI decreases the affinity of Gs-protein to guanine nucleotides and consequently inhibits the high-affinity state breakdown process of beta-adrenergic receptor in the receptor-AC coupling system of the rat cerebral cortex. However, DMI has no or little effect on Gi protein. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 58, 号 1, p. 15-24, 発行日 1989-02-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |