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抗HLA-A2.A28モノクローナル抗体に対する抗イディオタイプモノクローナル抗体の作製と免疫応答の解析
https://doi.org/10.15114/smj.58.1
https://doi.org/10.15114/smj.58.140b011d6-7aa7-4a44-8b49-6d8970bd2f1a
名前 / ファイル | ライセンス | アクション |
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n0036472X5811.pdf (816.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-08-16 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 抗HLA-A2.A28モノクローナル抗体に対する抗イディオタイプモノクローナル抗体の作製と免疫応答の解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Preparation and Immune Response of Ant-idiotypic Monoclonal Antibodies to Anti HLA-A2.A28 Monoclonal Antibodies | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Anti-idiotypic monoclonal antibody | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Internal image of antigen | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Idiotype mapping | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cancer therapy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.58.1 | |||||
ID登録タイプ | JaLC | |||||
著者 |
辻崎, 正幸
× 辻崎, 正幸× 今井, 浩三 |
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著者別名 | ||||||
姓名 | Tsujisaki, Masayuki | |||||
著者別名 | ||||||
姓名 | Imai, Kohzoh | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Model experiments using anti HLA monoclonal antibodies were performed to apply the immune response of anti-idiotypic antibodies to immunotherapy since anti-idiotypic antibodies are of interest in the investigation of a new immunomodulator for cancer patients.Polyclonal anti-idiotypic antisera and anti-idiotypic monoclonal antibodies induced with anti HLA-A2.A28 monoclonal antibody KS1 in a syngeneic system recognized the private idiotype on monoclonal amtibody KS1.Idiotype mapping of monoclonal antibody ES1 showed that there might be at least four idiotopes on it ; two idiotopes at a combining site and another at an intermediate site.The four diffrerent anti-idiotypic monoclonal antibodies might induce anti-anti-idiotypic antibodies specific to their immunized anti-idiotypic monoclonal antibody in the syngeneic system.One of the anti-idiotypic monoclonal antibodies against the idiotope at the combining site of monoclonal antibody KS1could induce an anti-anti-idiotypic antibody which might have the same reactivity as that of monoclonal antibody KS1 to HLA-A2.A28 antigen.The results suggest that an anti-idiotypic antibody bearing the internal image of a tumor associated antigen may induce the anti-anti-idiotypic antibodies specific to the tumor associated antigen and therefore may be useful for cancer therapy. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 58, 号 1, p. 1-13, 発行日 1989-02-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |