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口腔癌の潜在性頸部リソパ節転移に関する臨床的,病理組織学的研究
https://doi.org/10.15114/smj.62.43
https://doi.org/10.15114/smj.62.43f3d8038c-5241-473d-9ca0-1c736797e3a0
名前 / ファイル | ライセンス | アクション |
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n0036472X62143.pdf (769.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 口腔癌の潜在性頸部リソパ節転移に関する臨床的,病理組織学的研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Clinical and Histopathological Study on Occult Metastasis of Squamous Cell Carcinoma of the Oral Cavity | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Occult metastasis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Oral squamous cell carcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Histological malignancy score | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Quantification theory type II | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.62.43 | |||||
ID登録タイプ | JaLC | |||||
著者 |
宮川, 明
× 宮川, 明× 平塚, 博義× 小浜, 源郁 |
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著者別名 | ||||||
姓名 | Miyakawa, Akira | |||||
著者別名 | ||||||
姓名 | Hiratsuka, Hiroyoshi | |||||
著者別名 | ||||||
姓名 | Kohama, Gen-iku | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A retrospective analysis of one hundred and forty-one surgical cases of previously untreated squamous cell carcinoma of the oral cavity with no clinically positive nodes (N-O) was performed in order to elucidate the clinical and histopathological factors predicting occult nodal metastasis. Ninety-six of 141 patients were treated by peroral excision ; 80 of these had N-O during follow up ; the other 16 had delayed neck dissection when nodes became clinically involved. Forty-five of 141 patients were treated by excision of primary lesion combined with elective neck dissection. The frequencies of nodal involvement were 15.6% (15/96) in the former and 24.4% (ll/45) in the letter. The overall incidence of occult nodal metastasis was 18.4% (26/141). Patients with occult nodal metastasis had significantly lower 5-year cumulative survival rates than those with uninvolved nodes (44.1% vs 93.7%, p<0.001). The malignancy grading was based upon three different morphologic characteristics for the tumor cell population (type of differentiation, cellular atypism, mitotic index) and two characteristics for the tumor-host relationship (mononuclear inflammatory infiltrates, mode of cancer invasion). Patients with malignancy score≧10 had high risk of occult nodal metastasis regardless of tumor size ; those of score ≧14 showed particularly high risk of microscopic positive nodes. Quantification Theory Type II analysis was performed in an attempt to elucidate the relationship between, clinical and histopathological findings and occult nodal metastasis. The clinical (age, site, tumor size, growth pattern) and histopathological (type of differentiation, cellular atypism, degree of mitotic index, mode of cancer invasion) findings and the occurrence of nodal metastasis were related on the basis of the partial correlation coefficients. The contributions to occult nodal metastasis of each of the clinical and histopathological factors were, in descending order, mode of cancer invasion, site, tumor size, and type of differentiation of cancer cells. The discrimination ratio between microscopic positive and negative cervical lymph nodes was 90.1%. The histological malignancy score closely correlated with nodal status and appears to be a valid indicator for prediction of occult nodal metastasis. This criterion may serve in establishing the therapeutic course for cervical lymph nodes in occult metastasis. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 62, 号 1, p. 43-53, 発行日 1993-02-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |