WEKO3
アイテム
{"_buckets": {"deposit": "8ac556ca-bfa6-4910-a185-4bcc3d9df8f0"}, "_deposit": {"created_by": 14, "id": "14776", "owners": [14], "pid": {"revision_id": 0, "type": "depid", "value": "14776"}, "status": "published"}, "_oai": {"id": "oai:sapmed.repo.nii.ac.jp:00014776", "sets": ["1724"]}, "author_link": ["26137", "26138", "26139", "26134", "26135", "26136"], "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1993-02-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "8", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "62", "bibliographic_titles": [{"bibliographic_title": "札幌医学雑誌 = The Sapporo medical journal"}, {"bibliographic_title": "The Sapporo medical journal", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "kit ligand (KL), which was identified as the ligand for the tyrosine kinase receptor encoded by the proto-oncogene c-kit, has recently been shown to play an important role in prolifera- tion of primitive hematopoietic progenitor cells. KL is found both on the cell surface and in solu- tion, and alternative splicing has yielded two types of KL mRNAs. RT-PCR and Northern blot anal- ysis were performed on human epithelial tumors to determine whether c-kit and KL were expressed there. The results are summarized as follows. 1. KL mRNA was expressed in a wide variety of tissues including the placenta, spleen, liver, lung, kidney, stomach, duodenum and colon. The ratio of the expression level of the two types of KL mRNAs was almost constant in all those tissues. 2. Four hepatocellular carcinoma cell lines and a hepatoblastoma cell line expressed detectable levels of KL, but did not express c-kit 3. Among five colon carcinoma cell lines, Colo320DM and DLD-1 expressed both c-kit and KL. The expression of KIT protein was also confirmed by flow cytometry. 4. In Colo320DM, neither amplification nor rearrangement of c-kit gene was found.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "26137", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Toyota, Minoru"}]}, {"nameIdentifiers": [{"nameIdentifier": "26138", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hinoda, Yuji"}]}, {"nameIdentifiers": [{"nameIdentifier": "26139", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Imai, Kohzoh"}]}]}, "item_7_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.15114/smj.62.1", "subitem_identifier_reg_type": "JaLC"}]}, "item_7_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "札幌医科大学医学部"}]}, "item_7_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0036-472X", "subitem_source_identifier_type": "ISSN"}]}, "item_7_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "豊田, 実"}], "nameIdentifiers": [{"nameIdentifier": "26134", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "日野田, 裕治"}], "nameIdentifiers": [{"nameIdentifier": "26135", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "今井, 浩三"}], "nameIdentifiers": [{"nameIdentifier": "26136", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "n0036472X6211.pdf", "filesize": [{"value": "2.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2300000.0, "url": {"label": "n0036472X6211.pdf", "url": "https://sapmed.repo.nii.ac.jp/record/14776/files/n0036472X6211.pdf"}, "version_id": "b811e1e4-e3b7-4b93-b9fa-74f2e2800145"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "c-kit", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "kit Ligand", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Human epithelial tumors", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "上皮性腫瘍細胞におけるc-kit及びkit ligandの発現", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "上皮性腫瘍細胞におけるc-kit及びkit ligandの発現", "subitem_title_language": "ja"}, {"subitem_title": "Expression of c-kit and kit Ligand in Human Epithelial Tumors", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "14", "path": ["1724"], "permalink_uri": "https://doi.org/10.15114/smj.62.1", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-07-31"}, "publish_date": "2019-07-31", "publish_status": "0", "recid": "14776", "relation": {}, "relation_version_is_last": true, "title": ["上皮性腫瘍細胞におけるc-kit及びkit ligandの発現"], "weko_shared_id": -1}
上皮性腫瘍細胞におけるc-kit及びkit ligandの発現
https://doi.org/10.15114/smj.62.1
https://doi.org/10.15114/smj.62.15d2b4ddf-a03d-4738-95c0-bbe76dee75dd
名前 / ファイル | ライセンス | アクション |
---|---|---|
n0036472X6211.pdf (2.3 MB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 上皮性腫瘍細胞におけるc-kit及びkit ligandの発現 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Expression of c-kit and kit Ligand in Human Epithelial Tumors | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | c-kit | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | kit Ligand | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Human epithelial tumors | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.62.1 | |||||
ID登録タイプ | JaLC | |||||
著者 |
豊田, 実
× 豊田, 実× 日野田, 裕治× 今井, 浩三 |
|||||
著者別名 | ||||||
姓名 | Toyota, Minoru | |||||
著者別名 | ||||||
姓名 | Hinoda, Yuji | |||||
著者別名 | ||||||
姓名 | Imai, Kohzoh | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | kit ligand (KL), which was identified as the ligand for the tyrosine kinase receptor encoded by the proto-oncogene c-kit, has recently been shown to play an important role in prolifera- tion of primitive hematopoietic progenitor cells. KL is found both on the cell surface and in solu- tion, and alternative splicing has yielded two types of KL mRNAs. RT-PCR and Northern blot anal- ysis were performed on human epithelial tumors to determine whether c-kit and KL were expressed there. The results are summarized as follows. 1. KL mRNA was expressed in a wide variety of tissues including the placenta, spleen, liver, lung, kidney, stomach, duodenum and colon. The ratio of the expression level of the two types of KL mRNAs was almost constant in all those tissues. 2. Four hepatocellular carcinoma cell lines and a hepatoblastoma cell line expressed detectable levels of KL, but did not express c-kit 3. Among five colon carcinoma cell lines, Colo320DM and DLD-1 expressed both c-kit and KL. The expression of KIT protein was also confirmed by flow cytometry. 4. In Colo320DM, neither amplification nor rearrangement of c-kit gene was found. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 62, 号 1, p. 1-8, 発行日 1993-02-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |