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総説 : アレスチンの構造と機能
https://doi.org/10.15114/smj.65.159
https://doi.org/10.15114/smj.65.159aa87d619-5eb2-458e-a6cd-20766ee88fb0
名前 / ファイル | ライセンス | アクション |
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n0036472X652159.pdf (431.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 総説 : アレスチンの構造と機能 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | REVIEW : Structure and function of arrestins | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Arrestin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Autoimmune disease | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | G-protein-coupled receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Multiple sclerosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Desensitization | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.65.159 | |||||
ID登録タイプ | JaLC | |||||
著者 |
大黒, 浩
× 大黒, 浩 |
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著者別名 | ||||||
姓名 | Ourguro, Hiroshi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A review: Structure and function of arrestins Arrestin is a family of proteins that is involved in two different processes: (1) desensitization of the activated G-protein-coupled receptors, and (2) autoimmune diseases. This family consists of retinal arrestin, β-arrestin, invertebrate arrestin and their spliced variant forms. These proteins have high homologies in their functions and structures. Retinal arrestin was the first of the family to be identified and the most extensively studied so far. In vertebrate rod photoreceptors, rhodopsin absorbs light and is transformed to an active photobleaching intermediate called metarhodopsin II (mete II). Meta II activates several thousand molecules of a GTP binding protein called transducin, and is the substrate of rhodopsin kinase (RK). RK phosphorylates photoactivated rhodopsin at the C-terminal Ser and Thr residues. The phosphorylated photolyzed rhodopsin prevents transducin activation by binding arrestin. Retinal arrestin (called S-antigen) is also known to be a highly pathogenic molecule that induces uveotract inflammation in Mammalia. Recently, the author found serum autoantibodies against arrestin and β-arrestin in patients with multiple sclerosis and/or optic neuritis. In this article, I reviewed the latest information regarding the structure and functions of arrestins. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 65, 号 2, p. 159-165, 発行日 1996-04-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |