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癌関連網膜症の分子病態
https://doi.org/10.15114/smj.68.51
https://doi.org/10.15114/smj.68.5171ebdf59-5e00-42dd-bd2e-638a80fd79b9
名前 / ファイル | ライセンス | アクション |
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n0036472X68451.pdf (2.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 癌関連網膜症の分子病態 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Molecular Pathology of Cancer-associated Retinopathy | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cancer-associated retinopathy | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Melanoma-associated retinopathy | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Autoimmunity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CAR antigen | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.68.51 | |||||
ID登録タイプ | JaLC | |||||
著者 |
大黒, 浩
× 大黒, 浩× 前田, 亜希子× 池田, 陽子× 前田, 忠郎× 丸山, 幾代 |
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著者別名 | ||||||
姓名 | Ohguro, Hiroshi | |||||
著者別名 | ||||||
姓名 | Maeda, Akiko | |||||
著者別名 | ||||||
姓名 | Ikeda, Yoko | |||||
著者別名 | ||||||
姓名 | Maeda, Tadao | |||||
著者別名 | ||||||
姓名 | Ikuyo, Maruyama | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A variety of paraneoplastic syndrome affects the central nervous system including eye. So far, two types of retinopathy are known to be associated with patients with malignancies, CAR (cancer-associated retinopathy), and MAR (melanoma-associated retinopathy). CAR is associated with epithelial cancers, mostly lung small cell carcinoma, and is characterized by retinitis pigmentosa-like retinal degeneration. Usually CAR can be found before an underlying primary cancer is diagnosed. While MAR is associated with cutaneous malignant melanoma and is characterized by the relatively sudden onset of photopsia and nyctalopsia. The flash ERG (electroretinogram) of MAR patient shows an negative waveform, reduced b-wave amplitude and reservation of a-wave amplitude, suggesting bipolar cells may be affected. CAR and MAR are believed to result from autoimune basis. In CAR, a calcium binding protein called recoverin, 70 kDa protein and neurofilament are found to be the retinal antigens recognized by patient's sera. In contrast, the retinal antigens in MAR have not yet been identified, although patient sera specifically recognized retinal bipolar cells in immunocytochemistry. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 68, 号 4, p. 51-58, 発行日 1999-12-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |