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新規GVHD 診断マーカー : その臨床応用の可能性
https://doi.org/10.15114/smj.77.7
https://doi.org/10.15114/smj.77.79284fd46-5ede-4a4f-9036-1c012fe9038f
名前 / ファイル | ライセンス | アクション |
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n0036472X7717.pdf (537.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 新規GVHD 診断マーカー : その臨床応用の可能性 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | GVHD | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CCL8 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Biomarker | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Proteomics | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.77.7 | |||||
ID登録タイプ | JaLC | |||||
著者 |
堀, 司
× 堀, 司× 苗代, 康可× 相馬, 仁× 鈴木, 信寛× 畠山, 直樹× 山本, 雅樹× 園田, 智子× 水江, 由佳× 今井, 浩三 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although graft-versus-host disease (GVHD) is a life- threatening complication of hematopoietic stem cell transplantation (HSCT), current diagnosis mainly depends on clinical manifestations and invasive biopsies. Specific biomarkers for GVHD would facilitate early and accurate recognition of this grave condition. Using a proteomic approach, we screened for plasma proteins specific for GVHD in a mouse model. One peak with 8,972 m/z retained a discriminatory value in two diagnostic groups (GVHD and normal controls) with increased expression in the disease, decreased expression during cyclosporin A treatment and was barely detectable in syngeneic transplantation. Purification and mass analysis identified this molecule as CCL8, a member of a large chemokine family. In human samples, the serum concentration of CCL8 correlated closely with GVHD severity. All non-GVHD samples had low levels of CCL8. In sharp contrast, CCL8 was highly up-regulated in GVHD sera. CCL8 is a promising specific serum marker for the early and accurate diagnosis of GVHD. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 77, 号 1-6, p. 7-2, 発行日 2008-12-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |