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Analysis of Cellular Oncogene Amplification in Human Lung Cancers
https://doi.org/10.15114/tr.23.111
https://doi.org/10.15114/tr.23.111d8cbb0d6-0a0f-46db-94d1-dcd3393cc8a1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
n0041409323111.pdf (2.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||
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| 公開日 | 2019-07-31 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Analysis of Cellular Oncogene Amplification in Human Lung Cancers | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Oncogene | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Human lung cancer | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Gene amplification | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||
| ID登録 | ||||||||||||||||||
| ID登録 | 10.15114/tr.23.111 | |||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||
| 著者 |
Sugawara, Yoshitaka
× Sugawara, Yoshitaka
× Yoshida, Koichi
× Yamashita, Toshiharu
× Natori, Hiroshi
× Suzuki, Akira
× Fujinaga, Kei
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Twenty-six lung cancer tissues from operation or autopsy and eight lung cancer cell lines were examined for an amplification of the ten different cellular oncogenes, c-myc, N-myc, L-myc, c-erbB-1, c-erbB-2, c-fos, v-sis, c-H-ras, v-K-ras, and N-ras, by the Southern blot hybridization. In small cell lung cancer(SCLC), one SCLC tissue(13-1) out of four SCLC tissues and one SCLC cell line contained three fold amplifications of the L-myc oncogene. In non-SCLC, one adenocarcinoma cell line(SLO51) and one large cell carcinoma cell line(SLC-30) showed an amplification of the c-myc oncogene at four fold normal amount and twenty fold amplifications of the c-erbB-1 oncogene respectively, out of twenty-two non-SCLC tissues and seven non-SCLC cell lines. Other lung cancer tissues and cell lines did not show any detectable amplifications or rearrangements of oncogenes. These results suggest that an amplification of the studied oncogenes may not always be associated with carcinogenesis even in lung cancer cell lines. Compared with lung cancer cell lines, the frequency of an amplification of oncogenes in lung cancer tissues was low, especially in non-SCLC tissues. | |||||||||||||||||
| 書誌情報 |
Tumor Research en : Tumor Research 巻 23, p. 111-123, 発行日 1988 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 0041-4093 | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Sapporo Medical University | |||||||||||||||||
