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An Antiproliferative Monoclonal Antibody, 4F9, Reacts with a Subset of Human CD45 Molecules.
https://doi.org/10.15114/tr.27.37
https://doi.org/10.15114/tr.27.37f57746d3-2b44-4432-8b93-c78728655475
名前 / ファイル | ライセンス | アクション |
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n004140932737.pdf (2.4 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | An Antiproliferative Monoclonal Antibody, 4F9, Reacts with a Subset of Human CD45 Molecules. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CD45 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Growth inhibition | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Immunohistochemistry | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/tr.27.37 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Takahashi, Shuji
× Takahashi, Shuji× Sato, Noriyuki× Asanuma, Hiroko× Mori, Michio× Kikuchi, Kokichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The 4F9 monoclonal antibody (IgM) was established for its ability to induce mild growth inhibition to a human T cell line, SUP-T13. The antibody reacted with all hematopoietic cell lines, but not with nonhematopoietic cell lines. Im-munoprecipitation and immunoblotting experiments showed that 4F9 recognized cell surface molecules with apparent molecular weights of between 190 and 220 kDa which varied slightly in size among the cell lines. Therefore, it was strong-ly suggsted that 4F9 recognizes a subset of human CD45 molecules. In immuno-histochemical analysis with paraffin-embedded tissue sections, 4F9 reacted with most lymphocytes except for germinal center B cells in lymph nodes and both medullary and cortical thymocytes. The results of the present study indicated that the anti-CD45, such as 4F9 antibody, affect growth of malignant T cells. The 4F9 antibody is useful in the immunohistochemical analysis of CD45 mole-cules in paraffin-embedded tissue sections. | |||||
書誌情報 |
Tumor Research en : Tumor Research 巻 27, p. 37-49, 発行日 1992 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0041-4093 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Sapporo Medical University |