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Antitumor Activity of Activated Lymphocytes and Macrophages by Liposome-borne Tumor-specific Transplantation Antigens on Postsurgical Tumor Recurrence in Murine
https://doi.org/10.15114/tr.28.19
https://doi.org/10.15114/tr.28.196449542b-04d5-4eda-b4f7-f2304b3fdf88
名前 / ファイル | ライセンス | アクション |
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n004140932819.pdf (606.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Antitumor Activity of Activated Lymphocytes and Macrophages by Liposome-borne Tumor-specific Transplantation Antigens on Postsurgical Tumor Recurrence in Murine | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Liposome | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Tumor-specific transplantation antigens | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Macrophages | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Tumor infiltrating lymphocytes | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Crude butanol extracts | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/tr.28.19 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Sato, Takashi
× Sato, Takashi× Okazaki, Akira× Torimoto, Katsuji× Katsuramaki, Tadashi× Toda, Kazunori× Sato, Noriyuki× Kikuchi, Kokichi× Hirata, Koichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Liposome-borne tumor-specific transplantation antigens (TSTA) potentiated the antitumor activity of cytotoxic lymphocytes and macrophages (Mφ) much more efficiently than empty liposomes in murine. Mφ obtained from peritoneum and lung as well as cytotoxic T-lymphocytes (CTL) such as lymphokine-activat-ed killer (LAIC) cells and tumor infiltrating lymphocytes (TIL) showed higher inhibitory activity on metastatic tumor cell growth in lung. Among the effector lymphocytes in vivo, TIL showed desiable antitumor activity by way of intra-venous injection, while peritoneal Mφ showed high cytotoxicity by intraper-itoneal injection and intraveneously alveolar Mφ also showed high cytotoxic activity. These results suggest that the suitable administrations of liposome-borne TSTA may be useful in potentiating the tumoricidal effect of effector cells in vivo, especially TIL, CTL, and Mφ, and possibly may aid in overcoming tumor metastases. | |||||
書誌情報 |
Tumor Research en : Tumor Research 巻 28, p. 19-30, 発行日 1993 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0041-4093 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Sapporo Medical University |