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  1. 紀要
  2. Tumor Research
  3. Vol.30

Tumorigenicity, Motility and Liver Metastasis of Human Gastric Carcinoma Lines with High Metastatic Potential in the Liver of Nude Mice

https://doi.org/10.15114/tr.30.57
https://doi.org/10.15114/tr.30.57
b78c2ada-11d6-4bc3-8139-54d4992a25c6
名前 / ファイル ライセンス アクション
n004140933057.pdf n004140933057.pdf (1.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-07-31
タイトル
タイトル Tumorigenicity, Motility and Liver Metastasis of Human Gastric Carcinoma Lines with High Metastatic Potential in the Liver of Nude Mice
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Metastasis
キーワード
言語 en
主題Scheme Other
主題 Human gastric carcinoma
キーワード
言語 en
主題Scheme Other
主題 Motile activity
キーワード
言語 en
主題Scheme Other
主題 Growth activity
キーワード
言語 en
主題Scheme Other
主題 Nude mice
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
ID登録
ID登録 10.15114/tr.30.57
ID登録タイプ JaLC
著者 Denno, Ryuichi

× Denno, Ryuichi

Denno, Ryuichi

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Yasoshima, Takahiro

× Yasoshima, Takahiro

Yasoshima, Takahiro

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Hirata, Koichi

× Hirata, Koichi

Hirata, Koichi

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Kaya, Mitsunori

× Kaya, Mitsunori

Kaya, Mitsunori

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Fujinaga, Kei

× Fujinaga, Kei

Fujinaga, Kei

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Ura, Hideki

× Ura, Hideki

Ura, Hideki

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Shishido, Takayuki

× Shishido, Takayuki

Shishido, Takayuki

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Okada, Yojiro

× Okada, Yojiro

Okada, Yojiro

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抄録
内容記述タイプ Abstract
内容記述 To analyze the human gastric carcinoma metastasis to the liver, a human gastric carcinoma line, AZ521 was injected into the spleens of nude mice. Cells from the few liver metastatic foci of injected AZ521 were expanded in vitro and subsequently injected into the spleens of nude mice. By repeating these proce-dures five times, we were able to obtain a cell line, designated AZ-H5c, with high metastatic potential in nude mice. It was observed that animals had liver metastasis in 10 of 12 (83%) cases injected with AZ-H5c, whereas only 14% with parental AZ521. The growth activity in vivo of AZ-H5c cells is much more rapid than that of AZ521 cells, but its growth activity in vitro is slower. The mortile activity in vitro of AZ-H5c is stronger than that of AZ521. These results suggest that our model can provide a new approach to basic and clinical studies of cancer metastasis.
書誌情報 Tumor Research
en : Tumor Research

巻 30, p. 57-65, 発行日 1995
ISSN
収録物識別子タイプ ISSN
収録物識別子 0041-4093
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 Sapporo Medical University
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