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Identification of Antigenic Site Within hsc 70 by Serum Autoantibody in Patients with Cancer-associated Retinopathy
https://doi.org/10.15114/tr.34.49
https://doi.org/10.15114/tr.34.491b602dd6-f794-4aed-b73c-c0ab831164a8
名前 / ファイル | ライセンス | アクション |
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n004140933449.pdf (711.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Identification of Antigenic Site Within hsc 70 by Serum Autoantibody in Patients with Cancer-associated Retinopathy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Autoantigen | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Autoimmunity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cancer-associated retinopathy | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Heat shock protein | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/tr.34.49 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Maeda, Tadao
× Maeda, Tadao× Ohguro, Hiroshi× Maeda, Akiko× Nakagawa, Takashi× Ogawa, Keiichi× Hirai, Itaru× Sato, Noriyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In our previous studies, both recoverin and heat shock cognate protein 70 (hsc 70) were found as autoantigens recognized by sera from four patients with cancer-associated retinopathy (CAR) . In the present study on the mole-cular mechanism of antibody generation in CAR, we identified the antigenic site within hsc 70 by the patients' sera using deletion mutants of hsc 73. We expressed a series of deletion mutants of hsc 73 proteins and subjected then to western blot analysis. In western blot analysis, CAR patient's serum reacted with wild type hsp 70, but not with the C-terminal truncated mutants. This data demonstrated that the antigenic site was located within the C-terminus region of hsc 73 as identified by CAR patient's serum. | |||||
書誌情報 |
Tumor Research en : Tumor Research 巻 34, p. 49-56, 発行日 1999 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0041-4093 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Sapporo Medical University |