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Regulation of Anoikis
https://doi.org/10.15114/tr.36.1
https://doi.org/10.15114/tr.36.182822cf2-c066-4e97-a123-f43c2192a201
名前 / ファイル | ライセンス | アクション |
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n004140933611.pdf (88.7 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Regulation of Anoikis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Anoikis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Apoptosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Akt | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Bcl-2 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | BH3-only proteins | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Integrin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/tr.36.1 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Sakamoto, Hiroki
× Sakamoto, Hiroki× Adachi, Masaaki× Idogawa, Masashi× Nishimura, Susumu× Yasui, Hiroshi× Minami, Takae× Imai, Kohzoh |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Normal epithelial and endothelial cells require attachment to extracellular matrix (ECM) proteins to grow or survive. In these anchorage -dependent cells, loss of interaction with the ECM proteins triggers apoptosis which is termed anoikis. Anoikis undoubtedly plays an essential role in the development and organization of normal tissues through its inhibitory effect on unfavorable cellular proliferation at inappropriate locations. In this regard, anoikis contributes to the maintenance of the physiological state. Importantly, disturbance of anoikis may allow cell proliferation at inappropriate sites and thus may be tightly linked to cancer development. Indeed, we have found that suppression of anoikis promotes peritoneal dissemination or metastasis of several carcinoma cells. These data imply that clarification of the molecular mechanism which regulates anoikis will, in turn, greatly help the regulation of cancer progression. Here we summarize recent advances in the field of anoikis regulation. | |||||
書誌情報 |
Tumor Research en : Tumor Research 巻 36, p. 1-6, 発行日 2001 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0041-4093 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Sapporo Medical University |