WEKO3
アイテム
{"_buckets": {"deposit": "532d6aee-ddc2-418a-9bce-f876b0b17a06"}, "_deposit": {"created_by": 15, "id": "14189", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "14189"}, "status": "published"}, "_oai": {"id": "oai:sapmed.repo.nii.ac.jp:00014189", "sets": ["1663"]}, "author_link": ["23487", "23488", "23489", "23490", "23491", "23492", "23493", "23494"], "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "21", "bibliographicPageStart": "15", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "Tumor Research"}, {"bibliographic_title": "Tumor Research", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We assessed the anti-tumor and antimetastatic effects of angiogenic inhibitor TNP-470, 6-O- ( N-chloroacetyl-carbamoyl ) -fumagillol, semisynthtic analogue of fumagillin, on lymph node metastasis of human gastric carcinoma using our established orthotopic implantation model of AZL5G. This line was derived from a parental human gastric cancer cell line, AZ521, which had low capacity for metastasis. 5×106 cells were implanted orthotopically into the stomachs of nude mice, which had been randomly divided into 3 groups: a control group given saline solution, a group receiving 15 mg/kg TNP-470, a group receiving 30 mg/kg TNP-470. TNP-470 (15 or 30 mg/kg) was given s.c. on alternate days for 6 weeks from day 1 after orthotopic implantation. In the control group, lymph node metastasis developed in 5 of 6 mice (83.3%). Lymph node metastasis developed in 3 of 4 mice (75.0%) receiving of 15mg/kg TNP-470, and in 3 of 5 mice (60.0%) receiving of 30mg/kg TNP-470. TNP-470 was revealed to have no inhibitory effect on the incidence of lymph node metastasis. However, it was also observed that administration of 30mg/kg TNP-470 reduced the number of lymph node metastases statistically. The inhibitory effect on the production of vascular endothelial growth factor (VEGF) by AZL5G cells were not altered by TNP-470 administration at the concentration ranging from 10-1 to 103 ng/ml. These results indicate that administration of TNP-470 in co-administration cytotoxic agents may be effective on keeping micrometastases dormant in the clinical therapeutic strategy for gastric cancer patients.", "subitem_description_type": "Abstract"}]}, "item_7_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.15114/tr.36.15", "subitem_identifier_reg_type": "JaLC"}]}, "item_7_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Sapporo Medical University"}]}, "item_7_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0041-4093", "subitem_source_identifier_type": "ISSN"}]}, "item_7_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamaguchi, Koji"}], "nameIdentifiers": [{"nameIdentifier": "23487", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirata, Koichi"}], "nameIdentifiers": [{"nameIdentifier": "23488", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ura, Hideki"}], "nameIdentifiers": [{"nameIdentifier": "23489", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furuhata, Tomohisa"}], "nameIdentifiers": [{"nameIdentifier": "23490", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasutoshi"}], "nameIdentifiers": [{"nameIdentifier": "23491", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kihara, Chikashi"}], "nameIdentifiers": [{"nameIdentifier": "23492", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawakami, Masayo"}], "nameIdentifiers": [{"nameIdentifier": "23493", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Denno, Ryuichi"}], "nameIdentifiers": [{"nameIdentifier": "23494", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "n0041409336115.pdf", "filesize": [{"value": "127.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 127700.0, "url": {"label": "n0041409336115.pdf", "url": "https://sapmed.repo.nii.ac.jp/record/14189/files/n0041409336115.pdf"}, "version_id": "2ff8eba2-cc99-4690-a472-f114506d6163"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Gastric cancer cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lymph node metastasis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Orthotopic implantation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TNP-470", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Inhibitory Effect of TNP-470 on Lymph Node Metastasis of Human Gastric Carcinoma Line Established by Orthotopic Implantation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Inhibitory Effect of TNP-470 on Lymph Node Metastasis of Human Gastric Carcinoma Line Established by Orthotopic Implantation", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "15", "path": ["1663"], "permalink_uri": "https://doi.org/10.15114/tr.36.15", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-07-31"}, "publish_date": "2019-07-31", "publish_status": "0", "recid": "14189", "relation": {}, "relation_version_is_last": true, "title": ["Inhibitory Effect of TNP-470 on Lymph Node Metastasis of Human Gastric Carcinoma Line Established by Orthotopic Implantation"], "weko_shared_id": -1}
Inhibitory Effect of TNP-470 on Lymph Node Metastasis of Human Gastric Carcinoma Line Established by Orthotopic Implantation
https://doi.org/10.15114/tr.36.15
https://doi.org/10.15114/tr.36.157c6daf35-52b7-49b7-96fa-c0e90e591000
名前 / ファイル | ライセンス | アクション |
---|---|---|
n0041409336115.pdf (127.7 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Inhibitory Effect of TNP-470 on Lymph Node Metastasis of Human Gastric Carcinoma Line Established by Orthotopic Implantation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Gastric cancer cells | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Lymph node metastasis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Orthotopic implantation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | TNP-470 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/tr.36.15 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Yamaguchi, Koji
× Yamaguchi, Koji× Hirata, Koichi× Ura, Hideki× Furuhata, Tomohisa× Kimura, Yasutoshi× Kihara, Chikashi× Kawakami, Masayo× Denno, Ryuichi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We assessed the anti-tumor and antimetastatic effects of angiogenic inhibitor TNP-470, 6-O- ( N-chloroacetyl-carbamoyl ) -fumagillol, semisynthtic analogue of fumagillin, on lymph node metastasis of human gastric carcinoma using our established orthotopic implantation model of AZL5G. This line was derived from a parental human gastric cancer cell line, AZ521, which had low capacity for metastasis. 5×106 cells were implanted orthotopically into the stomachs of nude mice, which had been randomly divided into 3 groups: a control group given saline solution, a group receiving 15 mg/kg TNP-470, a group receiving 30 mg/kg TNP-470. TNP-470 (15 or 30 mg/kg) was given s.c. on alternate days for 6 weeks from day 1 after orthotopic implantation. In the control group, lymph node metastasis developed in 5 of 6 mice (83.3%). Lymph node metastasis developed in 3 of 4 mice (75.0%) receiving of 15mg/kg TNP-470, and in 3 of 5 mice (60.0%) receiving of 30mg/kg TNP-470. TNP-470 was revealed to have no inhibitory effect on the incidence of lymph node metastasis. However, it was also observed that administration of 30mg/kg TNP-470 reduced the number of lymph node metastases statistically. The inhibitory effect on the production of vascular endothelial growth factor (VEGF) by AZL5G cells were not altered by TNP-470 administration at the concentration ranging from 10-1 to 103 ng/ml. These results indicate that administration of TNP-470 in co-administration cytotoxic agents may be effective on keeping micrometastases dormant in the clinical therapeutic strategy for gastric cancer patients. | |||||
書誌情報 |
Tumor Research en : Tumor Research 巻 36, p. 15-21, 発行日 2001 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0041-4093 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Sapporo Medical University |