WEKO3
-
RootNode
アイテム
Methylated CpG Island Amplification of Representational Difference Analysis for Oral Cancer
https://doi.org/10.15114/tr.37.9
https://doi.org/10.15114/tr.37.901873f80-3472-44c7-9e7d-23c1f04eec44
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
n004140933719.pdf (101.7 kB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2019-07-31 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Methylated CpG Island Amplification of Representational Difference Analysis for Oral Cancer | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Methylation | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | CpG island | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Oral squamous cell carcinoma (OSCC) | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| ID登録 | ||||||||||||||
| ID登録 | 10.15114/tr.37.9 | |||||||||||||
| ID登録タイプ | JaLC | |||||||||||||
| 著者 |
Ogi, Kazuhiro
× Ogi, Kazuhiro
× Toyota, Minoru
× Kohama, Geniku
× Tokino, Takashi
|
|||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | CpG islands are G+C-rich regions approximately 1 kb long that are free of methylation and contain the promoters of many mammalian genes. It has been demonstrated that aberrant methylation of CpG islands is associated with gene silencing of tumor suppressor genes. To examine DNA methylation changes in oral squamous cell carcinoma (OSCC), we have applied a novel genome screening technique, methylated CpG island amplification coupled with representational difference analysis. Using DNA from an OSCC cell line as tester and DNA from normal tongue tissue as driver, DNA sequences aberrantly methylated in OSCC can be obtained. We therefore propose that MCA is a useful technique to study methylation and to isolate CpG islands differentially methylated in cancer. | |||||||||||||
| 書誌情報 |
Tumor Research en : Tumor Research 巻 37, p. 9-15, 発行日 2002 |
|||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0041-4093 | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Sapporo Medical University | |||||||||||||
