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Modest antiviral activity of Toll-like receptor 3 (TLR3) against
https://doi.org/10.15114/smj.81.21
https://doi.org/10.15114/smj.81.217e07fb67-1bbe-45b9-8cfe-eb31b95cb187
名前 / ファイル | ライセンス | アクション |
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n0036472x81121.pdf (395.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-13 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Modest antiviral activity of Toll-like receptor 3 (TLR3) against | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | innate immunity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | respiratory syncytial virus | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | toll-like receptor 3 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.81.21 | |||||
ID登録タイプ | JaLC | |||||
著者 |
WATANABE, Kazuto
× WATANABE, Kazuto× NAGAI, Kazushige× IGARASHI-OKITA, Lisa× TSUGAWA, Takeshi× HORI, Tsukasa× YOTO, Yuko× TSUTSUMI, Hiroyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Human respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections in infants and Toll-like receptors (TLRs) are the first line of host defense against such infections. In this study, we aimed to elucidate the antiviral effect of TLR3 against RSV infection. The human TLR3 gene was either transiently or stably overexpressed in A549 cells and they were infected with the Long strain of RSV. In both cases, RSV production determined by plaque assay was modestly but significantly decreased in the TLR3-overexpressed cells compared with control cells. Less interferon (IFN)-β, measured by ELISA, was produced in the supernatant of the TLR3- overexpressed cells. Neutralization of IFN-β in the supernatant of the TLR3-overexpressed cells failed to increase RSV production to the same level as controls. These results indicate that TLR3 has modest anti-RSV activity and IFN-β seems not to be a significant mediator of this activity. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 81, 号 1-6, p. 21-30, 発行日 2012 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |