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骨粗鬆症の疼痛発生メカニズム
https://doi.org/10.15114/smj.81.7
https://doi.org/10.15114/smj.81.75c473055-f50f-45ab-848a-847b988230ba
名前 / ファイル | ライセンス | アクション |
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n0036472x8117.pdf (636.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-13 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 骨粗鬆症の疼痛発生メカニズム | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | osteoporosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | bone resorption | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | bone pain | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | osteoclast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | bisphosphonate | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.81.7 | |||||
ID登録タイプ | JaLC | |||||
著者 |
射場, 浩介
× 射場, 浩介× 阿部, 恭久× 山下, 敏彦 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The nerve fibers extensively innervate bone. In addition to nerve fibers, several receptors and released many kinds of neuropeptides were identified in the bone. On the other hand, most of roles concerning receptors and neuropeptides in bone were still unknown. Recently, bone pain of musculoskeletal disease is recognized to be related pathological condition at increasing bone resorption. It is thought to be a mechanism that a highly acidic condition at a bone compartment due to proton released from activated osteoclast stimulated acid sensing receptor, and afferent signal induced bone pain. We evaluated the skeletal pain in ovariectomy (OVX) mice, which was known as a model postmenopausal osteoporosis using the examination for pain-like behavior and immunohistochemistry technique. Those pain-like behavior was assessed. The OVX mice showed a decrease in threshold value of pain, and the number of c-Fos immunoreactive neurons in the dorsal horn of the spinal cord increased in OVX mice. In addition, the effects of bisphosphonate which is the potent inhibitor of osteoclasts, improved a decrease in threshold value of pain and c-Fos expression. These results indicated that the acidic microenviroment created by bone-resorbing osteoclast could cause the skeletal pain associated with postmenopausal osteoporosis. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 81, 号 1-6, p. 7-12, 発行日 2012 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |