The Hollow fiber membrane oxygenator (TERMO)? was studied experimentally, and was then used for 11 open heart surgeries. In the experiment, hemolysis and the pressure gradient across the oxygenator were observed using a model circuit. In adult mongrel dogs, 5hour total bypasses were carried out for the evaluation of O2 and CO2 transfer. These experiments showed 70% O2 blowing was proper to maintain adequate blood PO2. In clinical cases perfusion time was 79.0±39.3 min. and VEO2/QB was 0.60±0.13 on the average. Even with 70% O2 blowing, the cases QB/Membrane area (M2) ratio was below 0.7, resulting in over-oxygenation. The optimal ratio may be 1.0 or so. CO2 transfer was good in all cases. This hollow fiber oxygenator has minimal priming volume and good O2 and CO2 transfer. Therefore it can be safely and easily used for clinical cases when the blowing O2 content and oxygenator size for each case are adequately selected.
ホローファイバー膜型人工肺の実験的ならびに臨床的検討
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